Drug interactions
Bumetanide + Ketoprofen
Severity: Moderate
Bumetanide and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can reduce the diuretic and antihypertensive effects of bumetanide and may increase the risk of acute kidney injury in volume-depleted patients or those with heart failure or kidney disease.
What this interaction means in plain words
Bumetanide and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, opposing loop diuretic action.
What to do
Monitor weight, fluid status, blood pressure, serum creatinine and electrolytes. Avoid prolonged NSAID use in patients with heart failure and increase the diuretic dose only if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Ketoprofen?
MediHelp rates the interaction as moderate. Bumetanide and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen can reduce the diuretic and antihypertensive effects of bumetanide and may increase the risk of acute kidney injury in volume-depleted patients or those with heart failure or kidney disease.
How serious is the interaction between Bumetanide and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, fluid status, blood pressure, serum creatinine and electrolytes. Avoid prolonged NSAID use in patients with heart failure and increase the diuretic dose only if needed.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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