Drug interactions
Bumetanide + Neomycin
Severity: Moderate
Bumetanide and Neomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics can add to aminoglycoside ototoxicity and nephrotoxicity. With oral neomycin the risk is mainly where systemic absorption occurs, such as renal impairment, inflamed bowel or prolonged high-dose therapy.
What this interaction means in plain words
Bumetanide and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Neomycin belongs to Anti Bacterial.
Why it happens
Additive ototoxic and nephrotoxic effects, with volume depletion increasing aminoglycoside exposure if absorbed.
What to do
Monitor renal function and hearing with prolonged neomycin use or renal impairment. Keep the patient hydrated and avoid high doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Neomycin?
MediHelp rates the interaction as moderate. Bumetanide and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics can add to aminoglycoside ototoxicity and nephrotoxicity. With oral neomycin the risk is mainly where systemic absorption occurs, such as renal impairment, inflamed bowel or prolonged high-dose therapy.
How serious is the interaction between Bumetanide and Neomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hearing with prolonged neomycin use or renal impairment. Keep the patient hydrated and avoid high doses.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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