Drug interactions
Bumetanide + Oxaprozin
Severity: Moderate
Bumetanide and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can diminish the diuretic and natriuretic response to loop diuretics like bumetanide. In patients with heart failure, cirrhosis or renal impairment this may cause fluid retention and, in volume-depleted patients, acute kidney injury.
What this interaction means in plain words
Bumetanide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, counteracting loop diuretic action.
What to do
Monitor weight, edema, blood pressure and renal function, and increase diuretic dose if response falls. Avoid the combination in patients with significant renal impairment or heart failure where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Oxaprozin?
MediHelp rates the interaction as moderate. Bumetanide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can diminish the diuretic and natriuretic response to loop diuretics like bumetanide. In patients with heart failure, cirrhosis or renal impairment this may cause fluid retention and, in volume-depleted patients, acute kidney injury.
How serious is the interaction between Bumetanide and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function, and increase diuretic dose if response falls. Avoid the combination in patients with significant renal impairment or heart failure where possible.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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