Drug interactions
Bumetanide + Umeclidinium-vilanterol
Severity: Moderate
Bumetanide and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bumetanide causes renal potassium loss, and vilanterol can further lower serum potassium by moving it into cells. The combination may increase hypokalemia and ECG changes, especially in patients with cardiac disease or if the beta-agonist dose is exceeded.
What this interaction means in plain words
Bumetanide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive hypokalemia from loop diuretic potassium wasting and beta2-mediated intracellular potassium shift.
What to do
Monitor serum potassium and magnesium, particularly at initiation and in patients with heart disease, and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Bumetanide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bumetanide causes renal potassium loss, and vilanterol can further lower serum potassium by moving it into cells. The combination may increase hypokalemia and ECG changes, especially in patients with cardiac disease or if the beta-agonist dose is exceeded.
How serious is the interaction between Bumetanide and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly at initiation and in patients with heart disease, and replace as needed.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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