Drug interactions
Bupropion + Daridorexant
Severity: Minor
Bupropion and Daridorexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daridorexant is a sedating orexin antagonist, and combining it with other CNS-active drugs may worsen next-day drowsiness and psychomotor impairment. Bupropion is typically activating, so the additive sedation is likely limited, but driving and alertness can still be affected.
What this interaction means in plain words
Bupropion and Daridorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Daridorexant belongs to Central Nervous System.
Why it happens
Possible additive CNS effects on psychomotor performance; no major pharmacokinetic interaction is established.
What to do
Start daridorexant at the lowest dose and advise patients about next-day impairment before driving. Reduce or stop daridorexant if daytime somnolence occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Bupropion with Daridorexant?
MediHelp rates the interaction as minor. Bupropion and Daridorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Daridorexant is a sedating orexin antagonist, and combining it with other CNS-active drugs may worsen next-day drowsiness and psychomotor impairment. Bupropion is typically activating, so the additive sedation is likely limited, but driving and alertness can still be affected.
How serious is the interaction between Bupropion and Daridorexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start daridorexant at the lowest dose and advise patients about next-day impairment before driving. Reduce or stop daridorexant if daytime somnolence occurs.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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