Drug interactions
Bupropion + Eluxadoline
Severity: Minor
Bupropion and Eluxadoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is a strong CYP2D6 inhibitor and may raise eluxadoline exposure, though eluxadoline's metabolism is incompletely characterized. The clinical significance is uncertain, but higher exposure could increase gastrointestinal and CNS adverse effects.
What this interaction means in plain words
Bupropion and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Possible inhibition of CYP2D6-mediated eluxadoline metabolism by bupropion; the mechanism is not firmly established.
What to do
No empiric dose change is required; monitor for constipation, abdominal pain, nausea and pancreatitis symptoms. Reassess therapy if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Bupropion with Eluxadoline?
MediHelp rates the interaction as minor. Bupropion and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion is a strong CYP2D6 inhibitor and may raise eluxadoline exposure, though eluxadoline's metabolism is incompletely characterized. The clinical significance is uncertain, but higher exposure could increase gastrointestinal and CNS adverse effects.
How serious is the interaction between Bupropion and Eluxadoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is required; monitor for constipation, abdominal pain, nausea and pancreatitis symptoms. Reassess therapy if adverse effects emerge.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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