Drug interactions
Bupropion + Fluphenazine
Severity: Moderate
Bupropion and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may increase fluphenazine levels by inhibiting CYP2D6, raising the risk of extrapyramidal symptoms and sedation. Both drugs can also lower seizure threshold.
What this interaction means in plain words
Bupropion and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion and additive seizure-threshold lowering.
What to do
Monitor for extrapyramidal symptoms and seizures, and reduce the fluphenazine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Bupropion with Fluphenazine?
MediHelp rates the interaction as moderate. Bupropion and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may increase fluphenazine levels by inhibiting CYP2D6, raising the risk of extrapyramidal symptoms and sedation. Both drugs can also lower seizure threshold.
How serious is the interaction between Bupropion and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and seizures, and reduce the fluphenazine dose if adverse effects appear.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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