Drug interactions
Bupropion + Iloperidone
Severity: Major
Bupropion and Iloperidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is metabolized by CYP2D6 and CYP3A4, and bupropion is a strong CYP2D6 inhibitor. Co-administration raises iloperidone exposure and may increase QT prolongation, sedation and orthostatic hypotension.
What this interaction means in plain words
Bupropion and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Bupropion inhibits CYP2D6, reducing iloperidone clearance.
What to do
Reduce the iloperidone dose by about half when used with a strong CYP2D6 inhibitor, and consider ECG monitoring. Return to the usual dose if bupropion is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Bupropion with Iloperidone?
MediHelp rates the interaction as major. Bupropion and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iloperidone is metabolized by CYP2D6 and CYP3A4, and bupropion is a strong CYP2D6 inhibitor. Co-administration raises iloperidone exposure and may increase QT prolongation, sedation and orthostatic hypotension.
How serious is the interaction between Bupropion and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the iloperidone dose by about half when used with a strong CYP2D6 inhibitor, and consider ECG monitoring. Return to the usual dose if bupropion is stopped.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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