Drug interactions
Bupropion + Lasmiditan
Severity: Minor
Bupropion and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness, somnolence and other CNS effects. Bupropion has little sedating action, so any additive effect is modest, though both may affect cognition and driving ability.
What this interaction means in plain words
Bupropion and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Possible additive CNS effects; no established pharmacokinetic interaction.
What to do
Advise patients not to drive for at least 8 hours after a lasmiditan dose and to report excessive dizziness or sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Bupropion with Lasmiditan?
MediHelp rates the interaction as minor. Bupropion and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan commonly causes dizziness, somnolence and other CNS effects. Bupropion has little sedating action, so any additive effect is modest, though both may affect cognition and driving ability.
How serious is the interaction between Bupropion and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive for at least 8 hours after a lasmiditan dose and to report excessive dizziness or sedation.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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