Drug interactions
Bupropion-naltrexone + Carbamazepine
Severity: Moderate
Bupropion-naltrexone and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces bupropion metabolism, lowering bupropion exposure and possibly reducing efficacy while altering metabolite levels.
What this interaction means in plain words
Bupropion-naltrexone and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP2B6 and other enzymes, increasing bupropion clearance.
What to do
Monitor for reduced efficacy and adjust bupropion dose within labeled maximum if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Carbamazepine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces bupropion metabolism, lowering bupropion exposure and possibly reducing efficacy while altering metabolite levels.
How serious is the interaction between Bupropion-naltrexone and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy and adjust bupropion dose within labeled maximum if needed.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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