Drug interactions
Bupropion-naltrexone + Cinacalcet
Severity: Moderate
Bupropion-naltrexone and Cinacalcet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may increase cinacalcet exposure, raising the risk of hypocalcemia and gastrointestinal effects.
What this interaction means in plain words
Bupropion-naltrexone and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Cinacalcet belongs to Miscellaneous.
Why it happens
CYP2D6 inhibition by bupropion reduces cinacalcet clearance.
What to do
Monitor serum calcium and PTH and adjust the cinacalcet dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Bupropion-naltrexone with Cinacalcet?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may increase cinacalcet exposure, raising the risk of hypocalcemia and gastrointestinal effects.
How serious is the interaction between Bupropion-naltrexone and Cinacalcet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH and adjust the cinacalcet dose as needed.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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