Drug interactions
Bupropion-naltrexone + Clomipramine
Severity: Major
Bupropion-naltrexone and Clomipramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion strongly inhibits CYP2D6 and can increase clomipramine concentrations. Both drugs also lower the seizure threshold, so seizure risk and tricyclic toxicity such as arrhythmia and anticholinergic effects are increased.
What this interaction means in plain words
Bupropion-naltrexone and Clomipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion-naltrexone belongs to Miscellaneous; Clomipramine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion reduces clomipramine clearance, with additive seizure-threshold lowering.
What to do
Avoid the combination if possible. If necessary, reduce clomipramine dose, monitor ECG and clomipramine levels, and watch for seizures.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Clomipramine?
MediHelp rates the interaction as major. Bupropion-naltrexone and Clomipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bupropion strongly inhibits CYP2D6 and can increase clomipramine concentrations. Both drugs also lower the seizure threshold, so seizure risk and tricyclic toxicity such as arrhythmia and anticholinergic effects are increased.
How serious is the interaction between Bupropion-naltrexone and Clomipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, reduce clomipramine dose, monitor ECG and clomipramine levels, and watch for seizures.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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