Drug interactions
Bupropion-naltrexone + Difelikefalin
Severity: Minor
Bupropion-naltrexone and Difelikefalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and CNS-active drugs may add to this. Bupropion is usually stimulating, so the effect is modest.
What this interaction means in plain words
Bupropion-naltrexone and Difelikefalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion-naltrexone belongs to Miscellaneous; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS effects; the interaction is predicted rather than established.
What to do
Monitor for sedation and dizziness. Counsel patients on caution when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Bupropion-naltrexone with Difelikefalin?
MediHelp rates the interaction as minor. Bupropion-naltrexone and Difelikefalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Difelikefalin can cause somnolence and dizziness, and CNS-active drugs may add to this. Bupropion is usually stimulating, so the effect is modest.
How serious is the interaction between Bupropion-naltrexone and Difelikefalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness. Counsel patients on caution when driving.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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