Drug interactions
Bupropion-naltrexone + Eliglustat
Severity: Major
Bupropion-naltrexone and Eliglustat: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is a strong CYP2D6 inhibitor and eliglustat is a CYP2D6 substrate, so eliglustat exposure rises. Higher levels may prolong PR, QTc and QRS intervals and cause arrhythmia, particularly when CYP3A inhibitors are also present.
What this interaction means in plain words
Bupropion-naltrexone and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion-naltrexone belongs to Miscellaneous; Eliglustat belongs to Miscellaneous.
Why it happens
Bupropion and its metabolites inhibit CYP2D6, reducing eliglustat metabolism.
What to do
Avoid the combination where possible; if unavoidable, reduce eliglustat dosing per labeling, obtain an ECG and monitor for arrhythmia. Never combine with additional CYP3A inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Eliglustat?
MediHelp rates the interaction as major. Bupropion-naltrexone and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bupropion is a strong CYP2D6 inhibitor and eliglustat is a CYP2D6 substrate, so eliglustat exposure rises. Higher levels may prolong PR, QTc and QRS intervals and cause arrhythmia, particularly when CYP3A inhibitors are also present.
How serious is the interaction between Bupropion-naltrexone and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, reduce eliglustat dosing per labeling, obtain an ECG and monitor for arrhythmia. Never combine with additional CYP3A inhibitors.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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