Drug interactions
Bupropion-naltrexone + Eluxadoline
Severity: Moderate
Bupropion-naltrexone and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may increase eluxadoline exposure through CYP2D6 inhibition, though eluxadoline metabolism is incompletely characterized. Higher exposure could increase adverse effects such as constipation, nausea and pancreatitis.
What this interaction means in plain words
Bupropion-naltrexone and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Possible CYP2D6 inhibition by bupropion reduces eluxadoline clearance.
What to do
Monitor for gastrointestinal adverse effects and abdominal pain suggesting pancreatitis. Consider reducing the eluxadoline dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Bupropion-naltrexone with Eluxadoline?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may increase eluxadoline exposure through CYP2D6 inhibition, though eluxadoline metabolism is incompletely characterized. Higher exposure could increase adverse effects such as constipation, nausea and pancreatitis.
How serious is the interaction between Bupropion-naltrexone and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects and abdominal pain suggesting pancreatitis. Consider reducing the eluxadoline dose if toxicity occurs.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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