Drug interactions
Bupropion-naltrexone + Haloperidol
Severity: Moderate
Bupropion-naltrexone and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is partly metabolized by CYP2D6, and bupropion can raise its levels. This may increase extrapyramidal effects and QT prolongation, and both drugs can lower the seizure threshold.
What this interaction means in plain words
Bupropion-naltrexone and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.
Why it happens
Bupropion inhibits CYP2D6, reducing haloperidol clearance; additive seizure threshold lowering.
What to do
Monitor for extrapyramidal symptoms, QTc and seizures, and reduce the haloperidol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Haloperidol?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is partly metabolized by CYP2D6, and bupropion can raise its levels. This may increase extrapyramidal effects and QT prolongation, and both drugs can lower the seizure threshold.
How serious is the interaction between Bupropion-naltrexone and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, QTc and seizures, and reduce the haloperidol dose if needed.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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