Drug interactions
Bupropion-naltrexone + Iloperidone
Severity: Moderate
Bupropion-naltrexone and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6, which metabolizes iloperidone, raising its levels and QT-prolonging potential. Antipsychotics also lower seizure threshold, so seizure risk can rise too.
What this interaction means in plain words
Bupropion-naltrexone and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Iloperidone belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion reduces iloperidone clearance.
What to do
Consider reducing the iloperidone dose by about half when a strong CYP2D6 inhibitor is added, and monitor ECG and for seizures. Restore the dose if bupropion is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Bupropion-naltrexone with Iloperidone?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion inhibits CYP2D6, which metabolizes iloperidone, raising its levels and QT-prolonging potential. Antipsychotics also lower seizure threshold, so seizure risk can rise too.
How serious is the interaction between Bupropion-naltrexone and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the iloperidone dose by about half when a strong CYP2D6 inhibitor is added, and monitor ECG and for seizures. Restore the dose if bupropion is stopped.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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