Drug interactions
Bupropion-naltrexone + Promethazine
Severity: Moderate
Bupropion-naltrexone and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine, a phenothiazine antihistamine, can lower the seizure threshold. With bupropion, the combined risk of seizures may increase.
What this interaction means in plain words
Bupropion-naltrexone and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Promethazine belongs to Respiratory.
Why it happens
Additive lowering of seizure threshold; promethazine is also a CYP2D6 substrate and bupropion may raise its levels.
What to do
Use the lowest effective doses and consider a non-sedating alternative antiemetic or antihistamine in patients with seizure risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Frequently asked questions
Can I take Bupropion-naltrexone with Promethazine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promethazine, a phenothiazine antihistamine, can lower the seizure threshold. With bupropion, the combined risk of seizures may increase.
How serious is the interaction between Bupropion-naltrexone and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and consider a non-sedating alternative antiemetic or antihistamine in patients with seizure risk factors.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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