Drug interactions
Buspirone + Ceritinib
Severity: Moderate
Buspirone and Ceritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 inhibitor and may raise buspirone exposure, increasing dizziness, drowsiness and nausea.
What this interaction means in plain words
Buspirone and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Ceritinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of buspirone.
What to do
Consider a lower buspirone starting dose and monitor for adverse effects. Titrate according to tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Buspirone with Ceritinib?
MediHelp rates the interaction as moderate. Buspirone and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a CYP3A4 inhibitor and may raise buspirone exposure, increasing dizziness, drowsiness and nausea.
How serious is the interaction between Buspirone and Ceritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower buspirone starting dose and monitor for adverse effects. Titrate according to tolerability.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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