Drug interactions
Buspirone + Dihydroergotamine
Severity: Moderate
Buspirone and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine has serotonin receptor agonist activity, and with buspirone it might add to serotonergic effects. The clinical significance is uncertain and reports are limited.
What this interaction means in plain words
Buspirone and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity at 5-HT receptors.
What to do
Monitor for signs of serotonin toxicity such as agitation, tremor and hyperthermia. Stop one of the agents if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Buspirone with Dihydroergotamine?
MediHelp rates the interaction as moderate. Buspirone and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine has serotonin receptor agonist activity, and with buspirone it might add to serotonergic effects. The clinical significance is uncertain and reports are limited.
How serious is the interaction between Buspirone and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, tremor and hyperthermia. Stop one of the agents if symptoms occur.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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