Drug interactions
Buspirone + Ergotamine
Severity: Moderate
Buspirone and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine has serotonergic receptor activity and buspirone is a 5-HT1A partial agonist, so serotonergic effects may be additive. The risk of serotonin syndrome is theoretical, and ergotamine's vasoconstriction is a separate concern.
What this interaction means in plain words
Buspirone and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
Additive serotonergic receptor activity.
What to do
Monitor for signs of serotonin toxicity and ergotism symptoms such as limb coldness or numbness. Stop the drugs if either appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Buspirone with Ergotamine?
MediHelp rates the interaction as moderate. Buspirone and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine has serotonergic receptor activity and buspirone is a 5-HT1A partial agonist, so serotonergic effects may be additive. The risk of serotonin syndrome is theoretical, and ergotamine's vasoconstriction is a separate concern.
How serious is the interaction between Buspirone and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity and ergotism symptoms such as limb coldness or numbness. Stop the drugs if either appears.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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