Drug interactions
Buspirone + Erythromycin lactobionate
Severity: Moderate
Buspirone and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and can raise buspirone concentrations markedly. Patients may develop excessive drowsiness, dizziness, and nausea.
What this interaction means in plain words
Buspirone and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of buspirone.
What to do
Reduce the buspirone dose or temporarily withhold it during erythromycin therapy, and monitor for sedation and dizziness. Consider a non-CYP3A4-inhibiting antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Buspirone with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Buspirone and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin inhibits CYP3A4 and can raise buspirone concentrations markedly. Patients may develop excessive drowsiness, dizziness, and nausea.
How serious is the interaction between Buspirone and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the buspirone dose or temporarily withhold it during erythromycin therapy, and monitor for sedation and dizziness. Consider a non-CYP3A4-inhibiting antibiotic.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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