Drug interactions
Buspirone + Fluconazole
Severity: Moderate
Buspirone and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can raise buspirone concentrations, causing more dizziness, drowsiness and nausea. The effect is less pronounced than with strong CYP3A4 inhibitors.
What this interaction means in plain words
Buspirone and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated first-pass and systemic metabolism of buspirone.
What to do
Start with a low buspirone dose and titrate by response. Reduce the dose if sedation or dizziness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Fluconazole?
MediHelp rates the interaction as moderate. Buspirone and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can raise buspirone concentrations, causing more dizziness, drowsiness and nausea. The effect is less pronounced than with strong CYP3A4 inhibitors.
How serious is the interaction between Buspirone and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low buspirone dose and titrate by response. Reduce the dose if sedation or dizziness develops.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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