Drug interactions
Buspirone + Gepirone
Severity: Moderate
Buspirone and Gepirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone and buspirone are both 5-HT1A agonists with serotonergic activity, and gepirone is an antidepressant. Taken together they may raise the risk of serotonin syndrome. Gepirone is also metabolized by CYP3A4, so any change in exposure should be considered.
What this interaction means in plain words
Buspirone and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Gepirone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity at 5-HT1A receptors.
What to do
Monitor for agitation, tremor, hyperreflexia, diaphoresis and fever, particularly when starting or increasing either drug. Stop one or both agents if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Buspirone with Gepirone?
MediHelp rates the interaction as moderate. Buspirone and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone and buspirone are both 5-HT1A agonists with serotonergic activity, and gepirone is an antidepressant. Taken together they may raise the risk of serotonin syndrome. Gepirone is also metabolized by CYP3A4, so any change in exposure should be considered.
How serious is the interaction between Buspirone and Gepirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, diaphoresis and fever, particularly when starting or increasing either drug. Stop one or both agents if serotonin syndrome develops.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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