Drug interactions
Buspirone + Stiripentol
Severity: Moderate
Buspirone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol affects CYP3A4 in both directions, and its net effect on buspirone exposure is unpredictable. Buspirone levels may rise or fall, causing either more adverse effects or reduced anxiolytic benefit.
What this interaction means in plain words
Buspirone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol both inhibits and induces CYP3A4, altering buspirone metabolism.
What to do
Monitor clinical response and adverse effects such as dizziness and sedation when starting or stopping stiripentol. Adjust the buspirone dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Buspirone with Stiripentol?
MediHelp rates the interaction as moderate. Buspirone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol affects CYP3A4 in both directions, and its net effect on buspirone exposure is unpredictable. Buspirone levels may rise or fall, causing either more adverse effects or reduced anxiolytic benefit.
How serious is the interaction between Buspirone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects such as dizziness and sedation when starting or stopping stiripentol. Adjust the buspirone dose according to response.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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