Drug interactions
Buspirone + Trimipramine
Severity: Minor
Buspirone and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine has only weak serotonin reuptake inhibition, so the serotonergic interaction with buspirone is mainly theoretical. Additive sedation may occur.
What this interaction means in plain words
Buspirone and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buspirone belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects of buspirone 5-HT1A agonism and trimipramine.
What to do
No routine change is needed. Monitor for sedation and signs of serotonin excess after starting or increasing doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Buspirone with Trimipramine?
MediHelp rates the interaction as minor. Buspirone and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimipramine has only weak serotonin reuptake inhibition, so the serotonergic interaction with buspirone is mainly theoretical. Additive sedation may occur.
How serious is the interaction between Buspirone and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for sedation and signs of serotonin excess after starting or increasing doses.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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