Drug interactions
Cabazitaxel + Levoketoconazole
Severity: Major
Cabazitaxel and Levoketoconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor, and cabazitaxel is mainly cleared by CYP3A4. Higher cabazitaxel exposure increases the risk of severe neutropenia and other toxicity.
What this interaction means in plain words
Cabazitaxel and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP3A4, reducing cabazitaxel clearance.
What to do
Avoid the combination; if unavoidable, reduce the cabazitaxel dose by about 25% and monitor blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cabazitaxel
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Cabazitaxel with Levoketoconazole?
MediHelp rates the interaction as major. Cabazitaxel and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor, and cabazitaxel is mainly cleared by CYP3A4. Higher cabazitaxel exposure increases the risk of severe neutropenia and other toxicity.
How serious is the interaction between Cabazitaxel and Levoketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if unavoidable, reduce the cabazitaxel dose by about 25% and monitor blood counts.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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