Drug interactions
Cabazitaxel + Nevirapine
Severity: Moderate
Cabazitaxel and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower cabazitaxel concentrations and reduce its antitumor efficacy. Cabazitaxel is extensively metabolized by CYP3A4, and labeling recommends avoiding strong inducers.
What this interaction means in plain words
Cabazitaxel and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing cabazitaxel clearance.
What to do
Where possible, switch to an antiretroviral without enzyme induction during cabazitaxel therapy. Otherwise monitor tumor response and neutropenia closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Nevirapine?
MediHelp rates the interaction as moderate. Cabazitaxel and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower cabazitaxel concentrations and reduce its antitumor efficacy. Cabazitaxel is extensively metabolized by CYP3A4, and labeling recommends avoiding strong inducers.
How serious is the interaction between Cabazitaxel and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, switch to an antiretroviral without enzyme induction during cabazitaxel therapy. Otherwise monitor tumor response and neutropenia closely.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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