Drug interactions
Caffeine + Propylhexedrine
Severity: Moderate
Caffeine and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sympathomimetic stimulants, and combined use may cause additive nervousness, tachycardia and increased blood pressure. Risk is higher with large doses or misuse of propylhexedrine.
What this interaction means in plain words
Caffeine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caffeine belongs to Miscellaneous; Propylhexedrine belongs to Respiratory.
Why it happens
Additive CNS and adrenergic stimulation.
What to do
Limit caffeine while propylhexedrine is used, and monitor heart rate and blood pressure in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Caffeine with Propylhexedrine?
MediHelp rates the interaction as moderate. Caffeine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sympathomimetic stimulants, and combined use may cause additive nervousness, tachycardia and increased blood pressure. Risk is higher with large doses or misuse of propylhexedrine.
How serious is the interaction between Caffeine and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit caffeine while propylhexedrine is used, and monitor heart rate and blood pressure in patients with cardiovascular disease.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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