Drug interactions
Caffeine + Rucaparib
Severity: Minor
Caffeine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP1A2, the main enzyme clearing caffeine, so caffeine exposure may rise. This may cause more jitteriness, palpitations, or insomnia with high caffeine intake.
What this interaction means in plain words
Caffeine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP1A2-mediated caffeine metabolism.
What to do
Advise patients to limit caffeine intake and watch for tremor, tachycardia, or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Caffeine with Rucaparib?
MediHelp rates the interaction as minor. Caffeine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP1A2, the main enzyme clearing caffeine, so caffeine exposure may rise. This may cause more jitteriness, palpitations, or insomnia with high caffeine intake.
How serious is the interaction between Caffeine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to limit caffeine intake and watch for tremor, tachycardia, or insomnia.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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