Drug interactions
Caffeine + Zileuton
Severity: Minor
Caffeine and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton inhibits CYP1A2, the main enzyme clearing caffeine, and raises caffeine levels and prolongs its half-life. Patients may notice jitteriness, insomnia, palpitations or tachycardia, especially with high intake.
What this interaction means in plain words
Caffeine and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2-mediated caffeine metabolism.
What to do
Advise patients to limit caffeine intake and watch for tremor, insomnia or palpitations. No dose change of zileuton is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Zileuton?
MediHelp rates the interaction as minor. Caffeine and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zileuton inhibits CYP1A2, the main enzyme clearing caffeine, and raises caffeine levels and prolongs its half-life. Patients may notice jitteriness, insomnia, palpitations or tachycardia, especially with high intake.
How serious is the interaction between Caffeine and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to limit caffeine intake and watch for tremor, insomnia or palpitations. No dose change of zileuton is needed.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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