Drug interactions
Calcifediol + Chlorthalidone
Severity: Moderate
Calcifediol and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone reduces urinary calcium excretion, and calcifediol increases calcium absorption. Together they can cause hypercalcemia, with risk of kidney impairment and arrhythmia.
What this interaction means in plain words
Calcifediol and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Chlorthalidone belongs to Cardiovascular.
Why it happens
Thiazide-enhanced renal calcium reabsorption adds to vitamin D-driven intestinal calcium absorption.
What to do
Monitor serum calcium regularly and adjust calcifediol or calcium supplements if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Chlorthalidone?
MediHelp rates the interaction as moderate. Calcifediol and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone reduces urinary calcium excretion, and calcifediol increases calcium absorption. Together they can cause hypercalcemia, with risk of kidney impairment and arrhythmia.
How serious is the interaction between Calcifediol and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium regularly and adjust calcifediol or calcium supplements if hypercalcemia develops.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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