Drug interactions
Calcifediol + Dexamethasone-neomycin-polymyxin
Severity: Minor
Calcifediol and Dexamethasone-neomycin-polymyxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing drugs can speed the breakdown of calcifediol and reduce vitamin D activity. Systemic corticosteroids also impair vitamin D effects on calcium handling, but topical dexamethasone adds little exposure.
What this interaction means in plain words
Calcifediol and Dexamethasone-neomycin-polymyxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcifediol belongs to Musculoskeletal; Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial.
Why it happens
Induced hydroxylation increases calcifediol clearance, and glucocorticoids antagonize vitamin D effects.
What to do
No action is needed for topical use; with prolonged systemic dexamethasone, monitor serum 25-hydroxyvitamin D and calcium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Dexamethasone-neomycin-polymyxin?
MediHelp rates the interaction as minor. Calcifediol and Dexamethasone-neomycin-polymyxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzyme-inducing drugs can speed the breakdown of calcifediol and reduce vitamin D activity. Systemic corticosteroids also impair vitamin D effects on calcium handling, but topical dexamethasone adds little exposure.
How serious is the interaction between Calcifediol and Dexamethasone-neomycin-polymyxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for topical use; with prolonged systemic dexamethasone, monitor serum 25-hydroxyvitamin D and calcium.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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