Drug interactions
Calcifediol + Dexamethasone
Severity: Minor
Calcifediol and Dexamethasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can impair vitamin D activity and calcium absorption, and enzyme induction may shorten calcifediol half-life. This may reduce the effectiveness of vitamin D therapy.
What this interaction means in plain words
Calcifediol and Dexamethasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcifediol belongs to Musculoskeletal; Dexamethasone belongs to Endocrine.
Why it happens
Dexamethasone induces hydroxylating enzymes that accelerate vitamin D metabolite catabolism.
What to do
Monitor serum calcium, phosphate, parathyroid hormone and 25-hydroxyvitamin D during prolonged co-therapy. Adjust calcifediol dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Dexamethasone?
MediHelp rates the interaction as minor. Calcifediol and Dexamethasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids can impair vitamin D activity and calcium absorption, and enzyme induction may shorten calcifediol half-life. This may reduce the effectiveness of vitamin D therapy.
How serious is the interaction between Calcifediol and Dexamethasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphate, parathyroid hormone and 25-hydroxyvitamin D during prolonged co-therapy. Adjust calcifediol dose as needed.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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