Drug interactions
Calcifediol + Oxcarbazepine
Severity: Moderate
Calcifediol and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing antiepileptics shorten the half-life of vitamin D metabolites, including calcifediol. Over time this can reduce vitamin D status and contribute to bone loss or osteomalacia.
What this interaction means in plain words
Calcifediol and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine induces hepatic hydroxylating enzymes, accelerating catabolism of calcifediol.
What to do
Monitor serum 25-hydroxyvitamin D, calcium and bone health, and increase the vitamin D dose if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Oxcarbazepine?
MediHelp rates the interaction as moderate. Calcifediol and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzyme-inducing antiepileptics shorten the half-life of vitamin D metabolites, including calcifediol. Over time this can reduce vitamin D status and contribute to bone loss or osteomalacia.
How serious is the interaction between Calcifediol and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum 25-hydroxyvitamin D, calcium and bone health, and increase the vitamin D dose if levels fall.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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