Drug interactions
Calcitriol + Calcium carbonate
Severity: Moderate
Calcitriol and Calcium carbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcitriol increases intestinal calcium absorption, so combining it with calcium carbonate can raise serum calcium. Hypercalcemia may occur, especially with high doses or renal impairment.
What this interaction means in plain words
Calcitriol and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcitriol belongs to Musculoskeletal; Calcium carbonate belongs to Gastrointestinal Tract.
Why it happens
Calcitriol enhances intestinal calcium absorption, adding to calcium supplied by calcium carbonate.
What to do
Monitor serum calcium and phosphate regularly and reduce calcitriol or calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Frequently asked questions
Can I take Calcitriol with Calcium carbonate?
MediHelp rates the interaction as moderate. Calcitriol and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcitriol increases intestinal calcium absorption, so combining it with calcium carbonate can raise serum calcium. Hypercalcemia may occur, especially with high doses or renal impairment.
How serious is the interaction between Calcitriol and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and phosphate regularly and reduce calcitriol or calcium dose if hypercalcemia develops.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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