Drug interactions
Calcitriol + Carbamazepine
Severity: Moderate
Calcitriol and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces vitamin D metabolism and can lower calcitriol effect, and long-term anticonvulsant use is associated with disturbed bone and calcium metabolism. Higher calcitriol doses may be needed.
What this interaction means in plain words
Calcitriol and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcitriol belongs to Musculoskeletal; Carbamazepine belongs to Central Nervous System.
Why it happens
Enzyme induction (CYP3A4) increasing calcitriol catabolism.
What to do
Monitor serum calcium, phosphate and PTH, and adjust the calcitriol dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Calcitriol with Carbamazepine?
MediHelp rates the interaction as moderate. Calcitriol and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces vitamin D metabolism and can lower calcitriol effect, and long-term anticonvulsant use is associated with disturbed bone and calcium metabolism. Higher calcitriol doses may be needed.
How serious is the interaction between Calcitriol and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphate and PTH, and adjust the calcitriol dose as needed.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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