Drug interactions
Calcitriol + Tazemetostat
Severity: Minor
Calcitriol and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and could modestly lower exposure to CYP3A4 substrates such as calcitriol. The clinical effect on calcitriol is expected to be small.
What this interaction means in plain words
Calcitriol and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcitriol belongs to Musculoskeletal; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tazemetostat may slightly increase calcitriol metabolism.
What to do
No routine adjustment is needed; check serum calcium if the response to calcitriol appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcitriol and Tazemetostat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Tazemetostat
Frequently asked questions
Can I take Calcitriol with Tazemetostat?
MediHelp rates the interaction as minor. Calcitriol and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and could modestly lower exposure to CYP3A4 substrates such as calcitriol. The clinical effect on calcitriol is expected to be small.
How serious is the interaction between Calcitriol and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; check serum calcium if the response to calcitriol appears reduced.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
