Drug interactions
Calcitriol + Tecovirimat
Severity: Minor
Calcitriol and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may slightly reduce exposure to CYP3A4 substrates. An effect on calcitriol is possible but likely small during the short courses typically used.
What this interaction means in plain words
Calcitriol and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcitriol belongs to Musculoskeletal; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tecovirimat may modestly increase calcitriol clearance.
What to do
No dose change is usually needed; monitor serum calcium if the patient is on long-term calcitriol and shows a reduced response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Calcitriol with Tecovirimat?
MediHelp rates the interaction as minor. Calcitriol and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and may slightly reduce exposure to CYP3A4 substrates. An effect on calcitriol is possible but likely small during the short courses typically used.
How serious is the interaction between Calcitriol and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor serum calcium if the patient is on long-term calcitriol and shows a reduced response.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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