Drug interactions
Calcium acetate + Digoxin
Severity: Moderate
Calcium acetate and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hypercalcemia increases myocardial sensitivity to digoxin and can precipitate arrhythmias. Oral calcium acetate used as a phosphate binder could raise calcium, especially in renal disease.
What this interaction means in plain words
Calcium acetate and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Digoxin belongs to Cardiovascular.
Why it happens
Elevated serum calcium augments digoxin's inotropic and arrhythmogenic effects.
What to do
Monitor serum calcium and ECG, avoiding hypercalcemia; separate dosing from digoxin by a couple of hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Digoxin?
MediHelp rates the interaction as moderate. Calcium acetate and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hypercalcemia increases myocardial sensitivity to digoxin and can precipitate arrhythmias. Oral calcium acetate used as a phosphate binder could raise calcium, especially in renal disease.
How serious is the interaction between Calcium acetate and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and ECG, avoiding hypercalcemia; separate dosing from digoxin by a couple of hours.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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