Drug interactions
Calcium acetate + Dolutegravir
Severity: Moderate
Calcium acetate and Dolutegravir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium acetate can bind dolutegravir in the gut and lower its absorption, risking reduced antiviral effect and resistance. The effect is largest when taken together while fasting.
What this interaction means in plain words
Calcium acetate and Dolutegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Dolutegravir belongs to Anti Virals.
Why it happens
Polyvalent calcium cations chelate dolutegravir in the gastrointestinal tract, decreasing absorption.
What to do
Give dolutegravir 2 hours before or 6 hours after calcium acetate, or take both together with food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Dolutegravir?
MediHelp rates the interaction as moderate. Calcium acetate and Dolutegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium acetate can bind dolutegravir in the gut and lower its absorption, risking reduced antiviral effect and resistance. The effect is largest when taken together while fasting.
How serious is the interaction between Calcium acetate and Dolutegravir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give dolutegravir 2 hours before or 6 hours after calcium acetate, or take both together with food.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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