Drug interactions
Calcium + Vitamin d
Severity: Moderate
Calcium and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D increases intestinal calcium absorption, so combining it with calcium supplements is usually beneficial. In some patients, especially with high doses, renal impairment or hyperparathyroidism, it can cause hypercalcemia and hypercalciuria.
What this interaction means in plain words
Calcium and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Vitamin D metabolites enhance intestinal calcium absorption and bone calcium mobilization, additively raising serum calcium.
What to do
Monitor serum calcium and renal function periodically, particularly with high-dose vitamin D or active analogues. Reduce the calcium or vitamin D dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Vitamin d
Frequently asked questions
Can I take Calcium with Vitamin d?
MediHelp rates the interaction as moderate. Calcium and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal calcium absorption, so combining it with calcium supplements is usually beneficial. In some patients, especially with high doses, renal impairment or hyperparathyroidism, it can cause hypercalcemia and hypercalciuria.
How serious is the interaction between Calcium and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically, particularly with high-dose vitamin D or active analogues. Reduce the calcium or vitamin D dose if hypercalcemia develops.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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