Drug interactions
Calcium carbonate + Crizotinib
Severity: Minor
Calcium carbonate and Crizotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib solubility falls as pH rises, so acid-reducing agents could theoretically lower exposure. No formal study exists and the effect of a short-acting antacid is uncertain.
What this interaction means in plain words
Calcium carbonate and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Crizotinib belongs to Oncology.
Why it happens
Raised gastric pH may reduce crizotinib dissolution; effect not formally established.
What to do
No fixed separation is established; consider taking calcium carbonate a couple of hours apart from crizotinib and monitor response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Crizotinib?
MediHelp rates the interaction as minor. Calcium carbonate and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib solubility falls as pH rises, so acid-reducing agents could theoretically lower exposure. No formal study exists and the effect of a short-acting antacid is uncertain.
How serious is the interaction between Calcium carbonate and Crizotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No fixed separation is established; consider taking calcium carbonate a couple of hours apart from crizotinib and monitor response.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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