Drug interactions
Calcium carbonate + Dasatinib
Severity: Moderate
Calcium carbonate and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib solubility falls as gastric pH rises, so antacids can lower its absorption and potentially reduce efficacy. Simultaneous antacid dosing notably reduced exposure in studies.
What this interaction means in plain words
Calcium carbonate and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Dasatinib belongs to Oncology.
Why it happens
Elevated gastric pH reduces dissolution of dasatinib, which has pH-dependent solubility.
What to do
Give the antacid at least 2 hours before or 2 hours after dasatinib. Prefer antacids over H2 blockers or proton pump inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Calcium carbonate with Dasatinib?
MediHelp rates the interaction as moderate. Calcium carbonate and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib solubility falls as gastric pH rises, so antacids can lower its absorption and potentially reduce efficacy. Simultaneous antacid dosing notably reduced exposure in studies.
How serious is the interaction between Calcium carbonate and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the antacid at least 2 hours before or 2 hours after dasatinib. Prefer antacids over H2 blockers or proton pump inhibitors.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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