Drug interactions
Calcium carbonate + Itraconazole
Severity: Moderate
Calcium carbonate and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole capsules need gastric acid to dissolve, so antacids can reduce absorption and cause subtherapeutic antifungal levels. This may lead to treatment failure in serious fungal infections.
What this interaction means in plain words
Calcium carbonate and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Itraconazole belongs to Anti Fungals.
Why it happens
Raised gastric pH reduces dissolution and absorption of itraconazole capsules.
What to do
Take itraconazole capsules at least 1 hour before or 2 hours after the antacid, with food; consider the oral solution or monitor levels in serious infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Itraconazole?
MediHelp rates the interaction as moderate. Calcium carbonate and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole capsules need gastric acid to dissolve, so antacids can reduce absorption and cause subtherapeutic antifungal levels. This may lead to treatment failure in serious fungal infections.
How serious is the interaction between Calcium carbonate and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take itraconazole capsules at least 1 hour before or 2 hours after the antacid, with food; consider the oral solution or monitor levels in serious infections.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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