Drug interactions
Calcium carbonate + Memantine
Severity: Minor
Calcium carbonate and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine clearance falls in alkaline urine, which can raise levels and increase adverse effects such as dizziness or confusion. Calcium carbonate alone has a modest effect on urine pH.
What this interaction means in plain words
Calcium carbonate and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Memantine belongs to Central Nervous System.
Why it happens
Urinary alkalinization reduces renal tubular secretion and increases reabsorption of memantine.
What to do
Monitor for CNS adverse effects if large antacid doses are used regularly or urinary pH is persistently alkaline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Calcium carbonate with Memantine?
MediHelp rates the interaction as minor. Calcium carbonate and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine clearance falls in alkaline urine, which can raise levels and increase adverse effects such as dizziness or confusion. Calcium carbonate alone has a modest effect on urine pH.
How serious is the interaction between Calcium carbonate and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects if large antacid doses are used regularly or urinary pH is persistently alkaline.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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