Drug interactions
Calcium carbonate + Moxifloxacin
Severity: Moderate
Calcium carbonate and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium can complex with moxifloxacin in the gut and lower its absorption, although the effect is smaller than with some other fluoroquinolones. Subtherapeutic levels could reduce antibacterial efficacy.
What this interaction means in plain words
Calcium carbonate and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Chelation of moxifloxacin by calcium ions reduces its intestinal absorption.
What to do
Give moxifloxacin at least 4 hours before or 8 hours after calcium-containing products, or follow the local label interval.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Moxifloxacin?
MediHelp rates the interaction as moderate. Calcium carbonate and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium can complex with moxifloxacin in the gut and lower its absorption, although the effect is smaller than with some other fluoroquinolones. Subtherapeutic levels could reduce antibacterial efficacy.
How serious is the interaction between Calcium carbonate and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give moxifloxacin at least 4 hours before or 8 hours after calcium-containing products, or follow the local label interval.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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