Drug interactions
Calcium carbonate + Mycophenolate mofetil
Severity: Moderate
Calcium carbonate and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium-containing antacids may reduce mycophenolate absorption, though the effect is typically modest. Lower exposure could reduce immunosuppressive effect.
What this interaction means in plain words
Calcium carbonate and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Reduced absorption via raised gastric pH and cation binding.
What to do
Separate administration by at least 2 hours and monitor for loss of immunosuppressive efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Calcium carbonate and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium-containing antacids may reduce mycophenolate absorption, though the effect is typically modest. Lower exposure could reduce immunosuppressive effect.
How serious is the interaction between Calcium carbonate and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 2 hours and monitor for loss of immunosuppressive efficacy.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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