Drug interactions
Calcium carbonate + Omadacycline
Severity: Moderate
Calcium carbonate and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium chelates tetracycline-class antibiotics such as omadacycline, decreasing oral absorption. This may lead to lower antibiotic exposure and reduced efficacy.
What this interaction means in plain words
Calcium carbonate and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Omadacycline belongs to Anti Bacterial.
Why it happens
Chelation of omadacycline by calcium cations in the gut impairs absorption.
What to do
Avoid taking calcium carbonate for at least 4 hours before and 4 hours after oral omadacycline. Consider intravenous omadacycline if calcium cannot be withheld.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Calcium carbonate with Omadacycline?
MediHelp rates the interaction as moderate. Calcium carbonate and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium chelates tetracycline-class antibiotics such as omadacycline, decreasing oral absorption. This may lead to lower antibiotic exposure and reduced efficacy.
How serious is the interaction between Calcium carbonate and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking calcium carbonate for at least 4 hours before and 4 hours after oral omadacycline. Consider intravenous omadacycline if calcium cannot be withheld.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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