Drug interactions
calcium carbonate + omeprazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Omeprazole-induced hypochlorhydria reduces absorption of calcium carbonate, lowering calcium bioavailability.
Mechanism of action
Pharmacokinetic: elevated gastric pH decreases dissolution/ionization of calcium carbonate, reducing intestinal absorption.
Clinical management
Prefer calcium citrate or administer calcium carbonate with meals; ensure adequate vitamin D; assess calcium intake and bone health in at-risk patients.
Drug reference
References
- Lexicomp Monograph: Calcium carbonate—Drug interactions — Lexicomp
- UpToDate: Calcium and vitamin D supplementation in adults — UpToDate
- SPS (UK): Using proton pump inhibitors with calcium supplements — SPS
Frequently asked questions
Can I take calcium carbonate with omeprazole?
The interaction is rated: Moderate. Omeprazole-induced hypochlorhydria reduces absorption of calcium carbonate, lowering calcium bioavailability.
How serious is the interaction between calcium carbonate and omeprazole?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between calcium carbonate and omeprazole managed?
Prefer calcium citrate or administer calcium carbonate with meals; ensure adequate vitamin D; assess calcium intake and bone health in at-risk patients.
Why do calcium carbonate and omeprazole interact?
Pharmacokinetic: elevated gastric pH decreases dissolution/ionization of calcium carbonate, reducing intestinal absorption.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.